The glutamate antagonist MK‐801 reduces focal ischemic brain damage in the rat

K. Park, C.; G. Nehls, Daniel; I. Graham, David; M. Teasdale, Graham; McCulloch, James

doi:10.1002/ana.410240411

Public

The glutamate antagonist MK‐801 reduces focal ischemic brain damage in the rat

Published in Annals of Neurology • Oct 1, 1988

Authors:

C. K. Park

Daniel G. Nehls

David I. Graham

Abstract

Excessive activation of the N-methyl-D-aspartate (NMDA) subtype of glutamate receptor has been implicated in the sequence of neurochemical events that results in irreversible neuronal damage in cerebral ischemia. The effects of the NMDA antagonist (+)-5-methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepte...

Subject

NMDA receptor

Anesthesia

Ischemia

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