Relationships between Hippocampal Atrophy, White Matter Disruption, and Gray Matter Hypometabolism in Alzheimer's Disease

Villain, Nicolas; Desgranges, Béatrice; Viader, Fausto; de La Sayette, Vincent; Mézenge, Florence; Landeau, Brigitte; Baron, Jean‐Claude; Eustache, Francis; Chételat, Gaël

doi:10.1523/jneurosci.1392-08.2008

Public

Relationships between Hippocampal Atrophy, White Matter Disruption, and Gray Matter Hypometabolism in Alzheimer's Disease

Published in Journal of Neuroscience • Jun 11, 2008

Authors:

Nicolas Villain

Béatrice Desgranges

Fausto Viader

Abstract

In early Alzheimer's disease (AD), the hippocampal region is the area most severely affected by cellular and structural alterations, yet glucose hypometabolism predominates in the posterior association cortex and posterior cingulate gyrus. One prevalent hypothesis to account for this discrepancy is ...

Subject

Posterior cingulate

White matter

Neuroscience

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