Strategies for the Assessment of Matrix Effect in Quantitative Bioanalytical Methods Based on HPLC−MS/MS

Matuszewski, B.K.; Constanzer, M.L.; Chavez-Eng, C.M.

doi:10.1021/ac020361s

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Strategies for the Assessment of Matrix Effect in Quantitative Bioanalytical Methods Based on HPLC−MS/MS

Published in Analytical Chemistry • Jun 4, 2003

Authors:

B.K. Matuszewski

M.L. Constanzer

C.M. Chavez-Eng

Abstract

In recent years, high-performance liquid chromatography (HPLC) with tandem mass spectrometric (MS/MS) detection has been demonstrated to be a powerful technique for the quantitative determination of drugs and metabolites in biological fluids. However, the common and early perception that utilization...

Subject

Bioanalysis

Chemistry

High-performance liquid chromatography

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