First Description of Azole-Resistant Aspergillus fumigatus Due to TR <sub>46</sub> /Y121F/T289A Mutation in France

Lavergne, Rose‐Anne; Morio, Florent; Favennec, Loïc; Dominique, S.; F. Meis, Jacques; Gargala, Gilles; E. Verweij, Paul; Le Pape, Patrice

doi:10.1128/aac.00127-15

Public

First Description of Azole-Resistant Aspergillus fumigatus Due to TR 46 /Y121F/T289A Mutation in France

Published in Antimicrobial Agents and Chemotherapy • Apr 28, 2015

Authors:

Rose‐Anne Lavergne

Florent Morio

Loïc Favennec

Abstract

Azole resistance in Aspergillus fumigatus is an emerging public health concern. Recently, a novel fungicide-driven mutation in the cyp51A gene and its promoter, TR46/Y121F/T289A, leading to high-level resistance to voriconazole has been identified in The Netherlands, Belgium, Germany, Denmark, Tanza...

Subject

Aspergillus fumigatus

Voriconazole

Azole

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