Selective activation of the M <sub>1</sub> muscarinic acetylcholine receptor achieved by allosteric potentiation

Ma, Lei; A. Seager, Matthew; Wittmann, Marion; A. Jacobson, Marlene; Bickel, Denise; Burno, Maryann; Jones, Keith; Kuzmick Graufelds, Valerie; Xu, Guangping; Pearson, Michelle; McCampbell, Alexander; C. Gaspar, Renee; J. Shughrue, Paul; Danziger, Andrew; P. Regan, Christopher; Flick, Rose; Pascarella, Danette; L. Garson, Susan; M. Doran, Scott; Kreatsoulas, Constantine; Veng, Lone; W. Lindsley, Craig; D. Shipe, William; D. Kuduk, Scott; Sur, Cyrille; G. Kinney, Gene; R. Seabrook, Guy; J. Ray, William

doi:10.1073/pnas.0900903106

Public

Selective activation of the M 1 muscarinic acetylcholine receptor achieved by allosteric potentiation

Published in Proceedings of the National Academy of Sciences • Aug 26, 2009

Authors:

Lei Ma

Matthew A. Seager

Marion Wittmann

Abstract

The forebrain cholinergic system promotes higher brain function in part by signaling through the M(1) muscarinic acetylcholine receptor (mAChR). During Alzheimer's disease (AD), these cholinergic neurons degenerate, therefore selectively activating M(1) receptors could improve cognitive function in ...

Subject

Allosteric regulation

Muscarinic acetylcholine receptor M4

Long-term potentiation

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