Lymphotoxin α/β and Tumor Necrosis Factor Are Required for Stromal Cell Expression of Homing Chemokines in B and T Cell Areas of the Spleen

N. Ngo, Vu; Körner, Heinrich; D. Gunn, Michael; Schmidt, Kerstin; Riminton, Sean; D. Cooper, Max; L. Browning, Jeffrey; D. Sedgwick, Jonathon; G. Cyster, Jason

doi:10.1084/jem.189.2.403

Public

Lymphotoxin α/β and Tumor Necrosis Factor Are Required for Stromal Cell Expression of Homing Chemokines in B and T Cell Areas of the Spleen

Published in The Journal of Experimental Medicine • Jan 18, 1999

Authors:

Vu N. Ngo

Heinrich Körner

Michael D. Gunn

Abstract

Mice deficient in the cytokines tumor necrosis factor (TNF) or lymphotoxin (LT) alpha/beta lack polarized B cell follicles in the spleen. Deficiency in CXC chemokine receptor 5 (CXCR5), a receptor for B lymphocyte chemoattractant (BLC), also causes loss of splenic follicles. Here we report that BLC ...

Subject

Lymphotoxin

CXCL13

Stromal cell

Research Assistant

AI chat, annotations, notes & similar papers

Finding related papers...

Discussions

(0)

No comments yet

Be the first to share your thoughts!