β-Catenin induces immortalization of melanocytes by suppressing <i> p16 <sup>INK4a</sup> </i> expression and cooperates with N-Ras in melanoma development

Delmas, Véronique; Beermann, Friedrich; Martinozzi, Silvia; Carreira, Suzanne; Ackermann, Julien; Y. Kumasaka, Mayuko; Denat, Laurence; Goodall, Jane; Luciani, Flavie; Virós, Amaya; Çallı Demirkan, Neşe; C. Bastian, Boris; R. Goding, Colin; Larue, Lionel

doi:10.1101/gad.450107

Public

β-Catenin induces immortalization of melanocytes by suppressing p16 INK4a expression and cooperates with N-Ras in melanoma development

Published in Genes & Development • Nov 15, 2007

Authors:

Véronique Delmas

Friedrich Beermann

Silvia Martinozzi

Abstract

Tumor progression is a multistep process in which proproliferation mutations must be accompanied by suppression of senescence. In melanoma, proproliferative signals are provided by activating mutations in NRAS and BRAF, whereas senescence is bypassed by inactivation of the p16(Ink4a) gene. Melanomas...

Subject

Biology

Melanoma

Wnt signaling pathway

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