Functional evidence of atypical β3‐adrenoceptors in the human colon using the β3‐selective adrenoceptor antagonist, SR 59230A

De Ponti, Fabrizio; Gibelli, Graziano; Croci, Tiziano; Arcidiaco, M; Crema, Francesca; Manara, L.

doi:10.1111/j.1476-5381.1996.tb15294.x

Public

Functional evidence of atypical β3‐adrenoceptors in the human colon using the β3‐selective adrenoceptor antagonist, SR 59230A

Published in British Journal of Pharmacology • Apr 1, 1996

Authors:

Fabrizio De Ponti

Graziano Gibelli

Tiziano Croci

Abstract

The role of beta 3-adrenoceptors in human colonic circular smooth muscle was assessed in vitro by use of the beta 3-selective antagonist SR 59230A. Isoprenaline, in the presence of the selective beta-adrenoceptor antagonists CGP 20712A (beta 1) and ICI 118551 (beta 2), both at 0.1 microM, concentrat...

Subject

Antagonist

Isoprenaline

Endocrinology

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