Preload induces troponin I degradation independently of myocardial ischemia.
Published in Circulation • Apr 24, 2001
Authors:,,
J Feng
B J Schaus
J A Fallavollita
Abstract
BACKGROUND: Although global ischemia induces troponin I (TnI) degradation, regional ischemia does not. We hypothesized that this disparity is related to preload-induced proteolysis, which varies as a function of the amount of myocardium at risk of ischemia. METHODS AND RESULTS: Isolated rat hearts w...
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