Angiopoietin-2 is associated with decreased endothelial nitric oxide and poor clinical outcome in severe falciparum malaria

Wen Yeo, Tsin; A. Lampah, Daniel; Gitawati, Retno; Tjitra, Emiliana; Kenangalem, Enny; A. Piera, Kim; N. Price, Ric; B. Duffull, Stephen; S. Celermajer, David; M. Anstey, Nicholas

doi:10.1073/pnas.0805782105

Public

Angiopoietin-2 is associated with decreased endothelial nitric oxide and poor clinical outcome in severe falciparum malaria

Published in Proceedings of the National Academy of Sciences • Oct 28, 2008

Authors:

Tsin Wen Yeo

Daniel A. Lampah

Retno Gitawati

Abstract

Adherence of parasitized erythrocytes to activated endothelium causes microvascular obstruction, tissue ischemia, and clinical complications in severe malaria (SM); however, the mechanisms leading to endothelial activation remain unclear. The angiogenic factors, angiopoietin-2 (Ang-2) and vascular e...

Subject

Endothelial activation

Endothelial dysfunction

Nitric oxide

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