<i>LRP6</i> Mutation in a Family with Early Coronary Disease and Metabolic Risk Factors

Mani, Arya; Mani, Arya; Radhakrishnan, Jayaram; Wang, He; Mani, Alaleh; Mani, Alaleh; Mani, Mohammad-Ali; Nelson‐Williams, Carol; S. Carew, Khary; Mane, Shrikant; Najmabadi, Hossein; Wu, Dan; P. Lifton, Richard

doi:10.1126/science.1136370

Public

LRP6 Mutation in a Family with Early Coronary Disease and Metabolic Risk Factors

Published in Science • Mar 2, 2007

Authors:

Arya Mani

Jayaram Radhakrishnan

Abstract

Coronary artery disease (CAD) is the leading cause of death worldwide and is commonly caused by a constellation of risk factors called the metabolic syndrome. We characterized a family with autosomal dominant early CAD, features of the metabolic syndrome (hyperlipidemia, hypertension, and diabetes),...

Subject

Missense mutation

Wnt signaling pathway

Genetics

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