Hypoxia affects mesoderm and enhances hemangioblast specification during early development.

DL, Ramírez-Bergeron; A, Runge; KD, Dahl; HJ, Fehling; G, Keller; MC, Simon

doi:10.1242/dev.01310

Public

Hypoxia affects mesoderm and enhances hemangioblast specification during early development.

Shared by NobleBlocks on Sep 1, 2004 • 12:00 AM UTC

Authors:

Ramírez-Bergeron DL

Runge A

Dahl KD

Abstract

Hypoxia Inducible Factor (HIF), consisting of HIF1alpha and ARNT (HIF1beta) subunits, activates multiple genes in response to oxygen (O(2)) deprivation. Arnt(-/-) mice exhibit substantial defects in blood cell and vessel development. We demonstrate that hypoxia accelerates the expression of Brachyur...

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