Hypoxia affects mesoderm and enhances hemangioblast specification during early development

L. Ramírez‐Bergeron, Diana; Runge, Anja; D. Cowden Dahl, Karen; Jörg Fehling, Hans; Keller, Gordon; Celeste Simon, M.

doi:10.1242/dev.01310

Public

Hypoxia affects mesoderm and enhances hemangioblast specification during early development

Published in Development • Sep 1, 2004

Authors:

Diana L. Ramírez‐Bergeron

Anja Runge

Karen D. Cowden Dahl

Abstract

Hypoxia Inducible Factor (HIF), consisting of HIF1alpha and ARNT (HIF1beta) subunits, activates multiple genes in response to oxygen (O(2)) deprivation. Arnt(-/-) mice exhibit substantial defects in blood cell and vessel development. We demonstrate that hypoxia accelerates the expression of Brachyur...

Subject

Hemangioblast

Biology

Cell biology

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