A recurrent 11q aberration pattern characterizes a subset of MYC-negative high-grade B-cell lymphomas resembling Burkitt lymphoma

Salaverría, Itziar; Martín‐Guerrero, Idoia; Wagener, Rabea; Kreuz, Markus; Köhler, Christian; Richter, Julia; Pieńkowska‐Grela, Barbara; Adam, Patrick; Burkhardt, Birgit; Claviez, Alexander; Damm‐Welk, Christine; G. Drexler, Hans; Hummel, Michael; S. Jaffe, Elaine; Küppers, Ralf; Lefebvre, Christine; Lisfeld, Jasmin; Löffler, Markus; A.F. MacLeod, Roderick; Nagel, Inga; Oschlies, Ilske; Rosołowski, Maciej; B. Russell, Robert; Rymkiewicz, Grzegorz; Schindler, Detlev; Schlesner, Matthias; Scholtysik, René; Schwäenen, Carsten; Spang, Rainer; Szczepanowski, Monika; Trümper, Lorenz; Vater, Inga; Weßendorf, Swen; Klapper, Wolfram; Siebert, Reiner

doi:10.1182/blood-2013-06-507996

Public

A recurrent 11q aberration pattern characterizes a subset of MYC-negative high-grade B-cell lymphomas resembling Burkitt lymphoma

Published in Blood • Jan 8, 2014

Authors:

Itziar Salaverría

Idoia Martín‐Guerrero

Rabea Wagener

Abstract

The genetic hallmark of Burkitt lymphoma (BL) is the t(8;14)(q24;q32) and its variants leading to activation of the MYC oncogene. It is a matter of debate whether true BL without MYC translocation exists. Here, we identified 59 lymphomas concordantly called BL by 2 gene expression classifiers among ...

Subject

Lymphoma

Chromosomal translocation

Burkitt's lymphoma

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