Regulatory Phosphorylation of AMPA-Type Glutamate Receptors by CaM-KII During Long-Term Potentiation

Barría, Andrés; Müller, Dominique; A. Derkach, V.; C. Griffith, Leslie; R. Soderling, Thomas

doi:10.1126/science.276.5321.2042

Public

Regulatory Phosphorylation of AMPA-Type Glutamate Receptors by CaM-KII During Long-Term Potentiation

Published in Science • Jun 27, 1997

Authors:

Andrés Barría

Dominique Müller

V. A. Derkach

Abstract

Long-term potentiation (LTP), a cellular model of learning and memory, requires calcium-dependent protein kinases. Induction of LTP increased the phosphorus-32 labeling of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-type glutamate receptors (AMPA-Rs), which mediate rapid excitato...

Subject

AMPA receptor

Long-term potentiation

Synaptic plasticity

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