Regulation of adipose branched-chain amino acid catabolism enzyme expression and cross-adipose amino acid flux in human obesity

E. Lackey, Denise; J. Lynch, Christopher; C. Olson, Kristine; Mostaedi, Rouzbeh; Ali, Mohamed; H. Smith, William; Karpe, Fredrik; M. Humphreys, Sandy; Bedinger, Daniel; N. Dunn, Tamara; P. Thomas, Anthony; J. Oort, Pieter; A. Kieffer, Dorothy; Amin, Rajesh; Bettaieb, Ahmed; G. Haj, Fawaz; A. Permana, Paska; G. Anthony, Tracy; H. Adams, Sean

doi:10.1152/ajpendo.00630.2012

Public

Regulation of adipose branched-chain amino acid catabolism enzyme expression and cross-adipose amino acid flux in human obesity

Published in American Journal of Physiology-Endocrinology and Metabolism • Mar 20, 2013

Authors:

Denise E. Lackey

Christopher J. Lynch

Kristine C. Olson

Abstract

Elevated blood branched-chain amino acids (BCAA) are often associated with insulin resistance and type 2 diabetes, which might result from a reduced cellular utilization and/or incomplete BCAA oxidation. White adipose tissue (WAT) has become appreciated as a potential player in whole body BCAA metab...

Subject

Internal medicine

Endocrinology

Insulin resistance

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