Epithelial barrier disruption allows nondisease-causing bacteria to initiate and sustain IBD in the IL-10 gene-deficient mouse

C. Sydora, Beate; M. MacFarlane, Sarah; Walker, John; L. Dmytrash, Andrea; A. Churchill, Thomas; Doyle, Jason; N. Fedorak, Richard

doi:10.1002/ibd.20155

Public

Epithelial barrier disruption allows nondisease-causing bacteria to initiate and sustain IBD in the IL-10 gene-deficient mouse

Published in Inflammatory Bowel Diseases • Apr 10, 2007

Authors:

Beate C. Sydora

Sarah M. MacFarlane

John Walker

Abstract

BACKGROUND: In the IL-10 gene-deficient mouse model, development of intestinal inflammation is associated with a defect in epithelial barrier integrity that is thought to allow sufficient passage of bacteria or bacterial antigens to initiate a mucosal immune response. Microbial monoassociation exper...

Subject

Inflammation

Biology

Immune system

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