Mechanisms of imprinting of the Prader–Willi/Angelman region

Horsthemke, Bernhard; Wagstaff, Joseph

doi:10.1002/ajmg.a.32364

Public

Mechanisms of imprinting of the Prader–Willi/Angelman region

Published in American Journal of Medical Genetics Part A • Jul 14, 2008

Authors:

Bernhard Horsthemke

Joseph Wagstaff

Abstract

Prader-Willi syndrome (PWS) and Angelman syndrome (AS) are two distinct neurodevelopmental disorders, each caused by several genetic and epigenetic mechanisms involving the proximal long arm of chromosome 15. Lack of a functional paternal copy of 15q11-q13 causes PWS; lack of a functional maternal c...

Subject

Angelman syndrome

Genomic imprinting

Imprinting (psychology)

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