Favorable outcome of patients with acute myeloid leukemia harboring a low-allelic burden FLT3-ITD mutation and concomitant NPM1 mutation: relevance to post-remission therapy

Pratcorona, Marta; Brunet, Salut; Nomdedéu, Josep; Ribera, Josep‐María; Tormo, Mar; F. Duarte, Rafael; Escoda, Lourdes; Guàrdia, Ramón; Paz Queipo De Llano, Maria; Salamero, Olga; Bargay, Joan; Pedro, Carmen; Martí, Josep; Torrebadell, Montserrat; Díaz‐Beyá, Marina; Camós, Mireia; Colomer, Dolors; Hoyos, Montserrat; Sierra, Jorge; Esteve, Jordi

doi:10.1182/blood-2012-06-431122

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Favorable outcome of patients with acute myeloid leukemia harboring a low-allelic burden FLT3-ITD mutation and concomitant NPM1 mutation: relevance to post-remission therapy

Published in Blood • Feb 1, 2013

Authors:

Marta Pratcorona

Salut Brunet

Josep Nomdedéu

Abstract

Risk associated to FLT3 internal tandem duplication (FLT3-ITD) in patients with acute myeloid leukemia (AML) may depend on mutational burden and its interaction with other mutations. We analyzed the effect of FLT3-ITD/FLT3 wild-type (FLT3wt) ratio depending on NPM1 mutation (NPM1mut) in 303 patients...

Subject

NPM1

Mutation

Concomitant

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