Association of Plasminogen Activator Inhibitor-Type 1 (-675 4G/5G) Polymorphism with Pre-Eclampsia: Systematic Review

Morgan, Jessie; Bombell, Sarah; McGuire, William

doi:10.1371/journal.pone.0056907

Public

Association of Plasminogen Activator Inhibitor-Type 1 (-675 4G/5G) Polymorphism with Pre-Eclampsia: Systematic Review

Published in PLoS ONE • Feb 15, 2013

Authors:

Jessie Morgan

Sarah Bombell

William McGuire

Abstract

BACKGROUND AND AIMS: Excessive generation of plasminogen activator inhibitor-type 1 (PAI-1) is implicated in the pathogenesis of pre-eclampsia and related conditions. The PAI-1 (-675 4G/5G) promoter polymorphism (rs1799889) affects transcriptional activity and is a putative genetic risk factor for p...

Subject

Odds ratio

Meta-analysis

Confidence interval

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