Anti‐tau antibody reduces insoluble tau and decreases brain atrophy

Yanamandra, Kiran; Jiang, Hong; E. Mahan, Thomas; E. Maloney, Susan; F. Wozniak, David; I. Diamond, Marc; M. Holtzman, David

doi:10.1002/acn3.176

Public

Anti‐tau antibody reduces insoluble tau and decreases brain atrophy

Published in Annals of Clinical and Translational Neurology • Jan 23, 2015

Authors:

Kiran Yanamandra

Hong Jiang

Thomas E. Mahan

Abstract

OBJECTIVE: We previously found a strong reduction in tau pathology and insoluble tau in P301S tau transgenic mice following intracerebroventricular infusion of the anti-tau antibody HJ8.5. We sought to determine the effects of HJ8.5 in the same model following peripheral administration. METHODS: The...

Subject

Atrophy

Piriform cortex

Neurodegeneration

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