Pathological TDP‐43 distinguishes sporadic amyotrophic lateral sclerosis from amyotrophic lateral sclerosis with
                    <i>SOD1</i>
                    mutations

R. A. Mackenzie, Ian; H. Bigio, Eileen; G. Ince, Paul; Geser, Felix; Neumann, Manuela; J. Cairns, Nigel; K. Kwong, Linda; S. Forman, Mark; Ravits, John; Stewart, Heather; Eisen, Andrew; McClusky, Leo; A. Kretzschmar, Hans; M. Monoranu, Camelia; Robin Highley, J.; Kirby, Janine; Siddique, Teepu; J. Shaw, Pamela; M‐Y. Lee, Virginia; Q. Trojanowski, John

doi:10.1002/ana.21147

Public

Pathological TDP‐43 distinguishes sporadic amyotrophic lateral sclerosis from amyotrophic lateral sclerosis with SOD1 mutations

Shared by NobleBlocks on Apr 27, 2007 • 12:00 AM UTC

Authors:

Ian R. A. Mackenzie

Eileen H. Bigio

Paul G. Ince

Abstract

Abstract Objective Amyotrophic lateral sclerosis (ALS) is a common, fatal motor neuron disorder with no effective treatment. Approximately 10% of cases are familial ALS (FALS), and the most common genetic abnormality is superoxide dismutase ‐ 1 ( SOD1 ) mutations. Most ALS research in the past decad...

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