Curcumin-loaded nanoparticles potently induce adult neurogenesis and reverse cognitive deficits in Alzheimer's disease model via canonical Wnt/β-catenin pathway.

Kant Tiwari, Shashi; Agarwal, Swati; Seth, Brashket; Yadav, Anuradha; Nair, Saumya; Bhatnagar, Priyanka; Karmakar, Madhumita; Kumari, Manisha; Kumar Singh Chauhan, Lalit; Kumar Patel, Devendra; Srivastava, Vikas; Singh, Dhirendra; Kumar Gupta, Shailendra; Tripathi, Anurag; Kumar Chaturvedi, Rajnish; Chand Gupta, Kailash

doi:10.1021/nn405077y

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Curcumin-loaded nanoparticles potently induce adult neurogenesis and reverse cognitive deficits in Alzheimer's disease model via canonical Wnt/β-catenin pathway.

Shared by NobleBlocks on Jan 28, 2014 • 12:00 AM UTC

Authors:

Shashi Kant Tiwari

Swati Agarwal

Brashket Seth

Abstract

Neurogenesis, a process of generation of new neurons, is reported to be reduced in several neurodegenerative disorders including Alzheimer's disease (AD). Induction of neurogenesis by targeting endogenous neural stem cells (NSC) could be a promising therapeutic approach to such diseases by influenci...

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