High Content Screening Identifies Decaprenyl-Phosphoribose 2′ Epimerase as a Target for Intracellular Antimycobacterial Inhibitors

Christophe, Thierry; Jackson, Mary; Kyoung Jeon, Hee; Fenistein, Denis; Contreras-Domínguez, Monica; Kim, Jaeseung; Genovesio, Auguste; Carralot, Jean‐Philippe; Ewann, Fanny; Hye Kim, Eun; Yeon Lee, Sae; Kang, Sun‐Hee; Jung Seo, Min; Jung Park, Eun; Škovierová, Henrieta; Phạm, Hà; Riccardi, Giovanna; Youn Nam, Ji; Marsollier, Laurent; Kempf, Marie; Joly‐Guillou, Marie‐Laure; Oh, Taegwon; Kyung Shin, Won; No, Zaesung; Nehrbass, Ulf; Brosch, Roland; T. Cole, Stewart; Brodin, Priscille

doi:10.1371/journal.ppat.1000645

Public

High Content Screening Identifies Decaprenyl-Phosphoribose 2′ Epimerase as a Target for Intracellular Antimycobacterial Inhibitors

Published in PLoS Pathogens • Oct 29, 2009

Authors:

Thierry Christophe

Mary Jackson

Hee Kyoung Jeon

Abstract

A critical feature of Mycobacterium tuberculosis, the causative agent of human tuberculosis (TB), is its ability to survive and multiply within macrophages, making these host cells an ideal niche for persisting microbes. Killing the intracellular tubercle bacilli is a key requirement for efficient t...

Subject

Antimycobacterial

Intracellular

High-content screening

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