Asparaginase antibody and asparaginase activity in children with higher-risk acute lymphoblastic leukemia: Children's Cancer Group Study CCG-1961.

EH, Panosyan; NL, Seibel; S, Martin-Aragon; PS, Gaynon; IA, Avramis; H, Sather; J, Franklin; J, Nachman; LJ, Ettinger; M, La; P, Steinherz; LJ, Cohen; SE, Siegel; VI, Avramis

doi:10.1097/00043426-200404000-00002

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Asparaginase antibody and asparaginase activity in children with higher-risk acute lymphoblastic leukemia: Children's Cancer Group Study CCG-1961.

Shared by NobleBlocks on Apr 1, 2004 • 12:00 AM UTC

Authors:

Panosyan EH

Seibel NL

Martin-Aragon S

Abstract

We investigated the anti-asparaginase antibody (Ab) and asparaginase enzymatic activity in the sera of 1,001 patients (CCG-1961) with high-risk acute lymphoblastic leukemia (HR-ALL). Patients received nine doses of native Escherichia coli asparaginase during induction. Half of rapid early responders...

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