Asparaginase Antibody and Asparaginase Activity in Children With Higher-Risk Acute Lymphoblastic Leukemia

H. Panosyan, Eduard; L. Seibel, Nita; Martín‐Aragón, Sagrario; S. Gaynon, Paul; A. Avramis, Ioannis; N. Sather, Harland; Franklin, Janet; B. Nachman, James; J. Ettinger, Lawrence; La, Mei; G. Steinherz, Peter; Cohen, Lewis; E. Siegel, Stuart; I. Avramis, Vassilios

doi:10.1097/00043426-200404000-00002

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Asparaginase Antibody and Asparaginase Activity in Children With Higher-Risk Acute Lymphoblastic Leukemia

Published in Journal of Pediatric Hematology/Oncology • Mar 25, 2004

Authors:

Eduard H. Panosyan

Nita L. Seibel

Sagrario Martín‐Aragón

Abstract

We investigated the anti-asparaginase antibody (Ab) and asparaginase enzymatic activity in the sera of 1,001 patients (CCG-1961) with high-risk acute lymphoblastic leukemia (HR-ALL). Patients received nine doses of native Escherichia coli asparaginase during induction. Half of rapid early responders...

Subject

Medicine

Asparaginase

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