Triptolide, a novel diterpenoid triepoxide fromTripterygium wilfordii Hook. f., suppresses the production and gene expression of pro-matrix metalloproteinases 1 and 3 and augments those of tissue inhibitors of metalloproteinases 1 and 2 in human synovial fibroblasts

Lin, Na; Sato, Takashi; Itô, Akira

doi:10.1002/1529-0131(200109)44:9<2193::aid-art373>3.0.co;2-5

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Triptolide, a novel diterpenoid triepoxide fromTripterygium wilfordii Hook. f., suppresses the production and gene expression of pro-matrix metalloproteinases 1 and 3 and augments those of tissue inhibitors of metalloproteinases 1 and 2 in human synovial fibroblasts

Published in Arthritis & Rheumatism • Jan 1, 2001

Authors:

Na Lin

Takashi Sato

Akira Itô

Abstract

OBJECTIVE: Various extracts of the Chinese herbal remedy Tripterygium wilfordii Hook. f. (TWHF) have been reported to be therapeutically efficacious in rheumatoid arthritis (RA) in China, but their mechanism of action remains unclear. We investigated the effect of triptolide, a diterpenoid triepoxid...

Subject

Triptolide

Tripterygium wilfordii

Matrix metalloproteinase

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