Human prostate cancer metastases target the hematopoietic stem cell niche to establish footholds in mouse bone marrow

Shiozawa, Yusuke; A. Pedersen, Elisabeth; M. Havens, Aaron; Jung, Younghun; Mishra, Anjali; Joseph, Jeena; Koo Kim, Jin; R. Patel, Lalit; Chi, Ying; M. Ziegler, Anne; J. Pienta, Michael; Song, Junhui; Wang, Jingcheng; D. Loberg, Robert; H. Krebsbach, Paul; J. Pienta, Kenneth; S. Taichman, Russell

doi:10.1172/jci43414

Public

Human prostate cancer metastases target the hematopoietic stem cell niche to establish footholds in mouse bone marrow

Published in Journal of Clinical Investigation • Mar 23, 2011

Authors:

Yusuke Shiozawa

Elisabeth A. Pedersen

Aaron M. Havens

Abstract

HSC homing, quiescence, and self-renewal depend on the bone marrow HSC niche. A large proportion of solid tumor metastases are bone metastases, known to usurp HSC homing pathways to establish footholds in the bone marrow. However, it is not clear whether tumors target the HSC niche during metastasis...

Subject

Homing (biology)

Niche

Bone marrow

Research Assistant

AI chat, annotations, notes & similar papers

Finding related papers...

Discussions

(0)

No comments yet

Be the first to share your thoughts!