Myostatin, a transforming growth factor-beta superfamily member, is expressed in heart muscle and is upregulated in cardiomyocytes after infarct.

M, Sharma; R, Kambadur; KG, Matthews; WG, Somers; GP, Devlin; JV, Conaglen; PJ, Fowke; JJ, Bass

doi:10.1002/(sici)1097-4652(199907)180:1<1::aid-jcp1>3.0.co;2-v

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Myostatin, a transforming growth factor-beta superfamily member, is expressed in heart muscle and is upregulated in cardiomyocytes after infarct.

Shared by NobleBlocks on Jul 1, 1999 • 12:00 AM UTC

Authors:

Sharma M

Kambadur R

Matthews KG

Abstract

Myostatin is a secreted growth and differentiating factor (GDF-8) that belongs to the transforming growth factor-beta (TGF-beta) superfamily. Targeted disruption of the myostatin gene in mice and a mutation in the third exon of the myostatin gene in double-muscled Belgian Blue cattle breed result in...

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