A Cellular Function for the RNA-Interference Enzyme Dicer in the Maturation of the <i>let-7</i> Small Temporal RNA

Hutvágner, György; McLachlan, Juanita; E. Pasquinelli, Amy; Bálint, Éva; Tuschl, Thomas; D. Zamore, Phillip

doi:10.1126/science.1062961

Public

A Cellular Function for the RNA-Interference Enzyme Dicer in the Maturation of the let-7 Small Temporal RNA

Published in Science • Aug 3, 2001

Authors:

György Hutvágner

Juanita McLachlan

Amy E. Pasquinelli

Abstract

The 21-nucleotide small temporal RNA (stRNA) let-7 regulates developmental timing in Caenorhabditis elegans and probably in other bilateral animals. We present in vivo and in vitro evidence that in Drosophila melanogaster a developmentally regulated precursor RNA is cleaved by an RNA interference-li...

Subject

Dicer

RNA interference

RNA

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