Phosphorylated Map Kinase (ERK1, ERK2) Expression is Associated with Early Tau Deposition in Neurones and Glial Cells, but not with Increased Nuclear DNA Vulnerability and Cell Death, in Alzheimer Disease, Pick's Disease, Progressive Supranuclear Palsy and Corticobasal Degeneration

Ferrer, Isidró; Blanco, Rosa; Carmona, Margarita; Ribera, R.; Goutan, E.; Puig, Berta; Rey, M.; Cardozo, Adriana; Viñals, Francesc; Ribalta, Teresa

doi:10.1111/j.1750-3639.2001.tb00387.x

Public

Phosphorylated Map Kinase (ERK1, ERK2) Expression is Associated with Early Tau Deposition in Neurones and Glial Cells, but not with Increased Nuclear DNA Vulnerability and Cell Death, in Alzheimer Disease, Pick's Disease, Progressive Supranuclear Palsy and Corticobasal Degeneration

Published in Brain Pathology • Apr 1, 2001

Authors:

Isidró Ferrer

Rosa Blanco

Margarita Carmona

Abstract

Abnormal tau phosphorylation and deposition in neurones and glial cells is one of the major features in taupathies. The present study examines the involvement of the Ras/MEK/ERK pathway of tau phosphorylation in Alzheimer disease (AD), Pick's disease (PiD), progressive supranuclear palsy (PSP) and c...

Subject

MAPK/ERK pathway

Phosphorylation

Progressive supranuclear palsy

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