Complex assembly, crystallization and preliminary X-ray crystallographic analysis of the human Rod–Zwilch–ZW10 (RZZ) complex

Altenfeld, Anika; Wohlgemuth, Sabine; Marie Wehenkel, Anne; R. Vetter, Ingrid; Musacchio, Andrea

doi:10.1107/s2053230x15004343

Public

Complex assembly, crystallization and preliminary X-ray crystallographic analysis of the human Rod–Zwilch–ZW10 (RZZ) complex

Published in Acta Crystallographica Section F Structural Biology Communications • Mar 19, 2015

Authors:

Anika Altenfeld

Sabine Wohlgemuth

Anne Marie Wehenkel

Abstract

The spindle-assembly checkpoint (SAC) monitors kinetochore-microtubule attachment during mitosis. In metazoans, the three-subunit Rod-Zwilch-ZW10 (RZZ) complex is a crucial SAC component that interacts with additional SAC-activating and SAC-silencing components, including the Mad1-Mad2 complex and c...

Subject

Protein subunit

Crystallization

Biology

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