ATP Activates a Reactive Oxygen Species-dependent Oxidative Stress Response and Secretion of Proinflammatory Cytokines in Macrophages

M. Cruz, Cristiane; Rinna, Alessandra; Jay Forman, Henry; Lúcia Marques Ventura, Ana; M. Persechini, Pedro; M. Ojcius, David

doi:10.1074/jbc.m608083200

Public

ATP Activates a Reactive Oxygen Species-dependent Oxidative Stress Response and Secretion of Proinflammatory Cytokines in Macrophages

Published in Journal of Biological Chemistry • Nov 29, 2006

Authors:

Cristiane M. Cruz

Alessandra Rinna

Henry Jay Forman

Abstract

Secretion of the proinflammatory cytokines, interleukin (IL)-1beta and IL-18, usually requires two signals. The first, due to microbial products such as lipopolysaccharide, initiates transcription of the cytokine genes and accumulation of the precursor proteins. Cleavage and secretion of the cytokin...

Subject

Proinflammatory cytokine

Inflammasome

Secretion

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