Deletion of the Selenocysteine tRNA Gene in Macrophages and Liver Results in Compensatory Gene Induction of Cytoprotective Enzymes by Nrf2

Suzuki, Takafumi; P. Kelly, Vincent; Motohashi, Hozumi; Nakajima, Osamu; Takahashi, Satoru; Nishimura, Susumu; Yamamoto, Masayuki

doi:10.1074/jbc.m708352200

Public

Deletion of the Selenocysteine tRNA Gene in Macrophages and Liver Results in Compensatory Gene Induction of Cytoprotective Enzymes by Nrf2

Published in Journal of Biological Chemistry • Nov 26, 2007

Authors:

Takafumi Suzuki

Vincent P. Kelly

Hozumi Motohashi

Abstract

The selenocysteine tRNA (tRNA(Sec)) molecule is the sight of synthesis for the amino acid selenocysteine and the adaptor for its translational insertion into selenoprotein enzymes, the majority of which contribute to cellular redox homeostasis. To examine the consequences of selenoprotein depletion ...

Subject

Selenocysteine

Selenoprotein

Biology

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