Differential Regulation of Caspase-1 Activation, Pyroptosis, and Autophagy via Ipaf and ASC in Shigella-Infected Macrophages

Suzuki, Toshihiko; Franchi, Luigi; Toma, Claudia; Ashida, Hiroshi; Ogawa, Michinaga; Yoshikawa, Yuko; Mimuro, Hitomi; Inohara, Naohiro; Sasakawa, Chihiro; Núñez, Gabriel

doi:10.1371/journal.ppat.0030111

Public

Differential Regulation of Caspase-1 Activation, Pyroptosis, and Autophagy via Ipaf and ASC in Shigella-Infected Macrophages

Published in PLoS Pathogens • Aug 8, 2007

Authors:

Toshihiko Suzuki

Luigi Franchi

Claudia Toma

Abstract

Shigella infection, the cause of bacillary dysentery, induces caspase-1 activation and cell death in macrophages, but the precise mechanisms of this activation remain poorly understood. We demonstrate here that caspase-1 activation and IL-1beta processing induced by Shigella are mediated through Ipa...

Subject

Pyroptosis

Shigella

Microbiology

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