Antidepressant Effects of TrkB Ligands on Depression-Like Behavior and Dendritic Changes in Mice After Inflammation

Zhang, Ji‐chun; Wu, Jin; Fujita, Yūkō; Yao, Wei; Ren, Qian; Yang, Chun; Li, Su‐Xia; Shirayama, Yukihiko; Hashimoto, Kenji

doi:10.1093/ijnp/pyu077

Public

Antidepressant Effects of TrkB Ligands on Depression-Like Behavior and Dendritic Changes in Mice After Inflammation

Published in The International Journal of Neuropsychopharmacology • Jan 26, 2015

Authors:

Ji‐chun Zhang

Jin Wu

Yūkō Fujita

Abstract

BACKGROUND: Brain-derived neurotrophic factor (BDNF) and its receptor, tropomyosin-related kinase B (TrkB), signaling represent potential therapeutic targets for major depressive disorder. The purpose of this study is to examine whether TrkB ligands show antidepressant effects in an inflammation-ind...

Subject

Tropomyosin receptor kinase B

Brain-derived neurotrophic factor

Antidepressant

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