The high Nrf2 expression in human acute myeloid leukemia is driven by NF-κB and underlies its chemo-resistance

A. Rushworth, Stuart; Zaitseva, Lyubov; Y. Murray, Megan; Shah, Niraj; M. Bowles, Kristian; J. MacEwan, David

doi:10.1182/blood-2012-04-422121

Public

The high Nrf2 expression in human acute myeloid leukemia is driven by NF-κB and underlies its chemo-resistance

Published in Blood • Oct 18, 2012

Authors:

Stuart A. Rushworth

Lyubov Zaitseva

Megan Y. Murray

Abstract

NF-E2-related factor 2 (Nrf2) transcription factor regulates a range of cytoprotective transcriptional responses, preventing further cellular injury by removing biochemical damage and renewing tissue. Here we show that acute myeloid leukemia (AML) cells possess greater constitutive nuclear levels of...

Subject

Gene knockdown

Cancer research

Myeloid leukemia

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