Early sorafenib-induced toxicity is associated with drug exposure and UGTIA9 genetic polymorphism in patients with solid tumors: a preliminary study.

Pascaline, Boudou-Rouquette,; Céline, Narjoz,; Jean Louis, Golmard,; Audrey, Thomas-Schoemann,; Olivier, Mir,; Fabrice, Taieb,; Jean-Philippe, Durand,; Romain, Coriat,; Alain, Dauphin,; Michel, Vidal,; Michel, Tod,; Marie-Anne, Loriot,; François, Goldwasser,; Benoit, Blanchet,

doi:10.1371/journal.pone.0042875

Public

Early sorafenib-induced toxicity is associated with drug exposure and UGTIA9 genetic polymorphism in patients with solid tumors: a preliminary study.

Published in PloS one • Jan 1, 2012

Authors:

Boudou-Rouquette, Pascaline

Narjoz, Céline

Golmard, Jean Louis

Abstract

BACKGROUND: Identifying predictive biomarkers of drug response is of key importance to improve therapy management and drug selection in cancer therapy. To date, the influence of drug exposure and pharmacogenetic variants on sorafenib-induced toxicity remains poorly documented. The aim of this pharma...

Subject

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Antineoplastic Agents

Area Under Curve

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