Phase I trial of hydroxychloroquine with dose-intense temozolomide in patients with advanced solid tumors and melanoma

Rangwala, Reshma; D. Leone, Robert; C Chang, Yunyoung; A. Fecher, Leslie; M. Schuchter, Lynn; Kramer, Amy; Tan, Kay-See; F. Heitjan, Daniel; Rodgers, Glenda; Gallagher, Maryann; Piao, Shengfu; B. Troxel, Andrea; L. Evans, Tracey; DeMichele, Angela; L. Nathanson, Katherine; J. O’Dwyer, Peter; Kaiser, Jonathon; Pontiggia, Laura; E. Davis, Lisa; K. Amaravadi, Ravi

doi:10.4161/auto.29118

Public

Phase I trial of hydroxychloroquine with dose-intense temozolomide in patients with advanced solid tumors and melanoma

Published in Autophagy • May 20, 2014

Authors:

Reshma Rangwala

Robert D. Leone

Yunyoung C Chang

Abstract

Blocking autophagy with hydroxychloroquine (HCQ) augments cell death associated with alkylating chemotherapy in preclinical models. This phase I study evaluated the maximum tolerated dose (MTD), safety, preliminary activity, pharmacokinetics, and pharmacodynamics of HCQ in combination with dose-inte...

Subject

Temozolomide

Medicine

Hydroxychloroquine

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