Antitumor triptycene bisquinones induce a caspase-independent release of mitochondrial cytochrome c and a caspase-2-mediated activation of initiator caspase-8 and -9 in HL-60 cells by a mechanism which does not involve Fas signaling.

EM, Perchellet; Y, Wang; RL, Weber; K, Lou; DH, Hua; JP, Perchellet

doi:10.1097/00001813-200411000-00002

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Antitumor triptycene bisquinones induce a caspase-independent release of mitochondrial cytochrome c and a caspase-2-mediated activation of initiator caspase-8 and -9 in HL-60 cells by a mechanism which does not involve Fas signaling.

Shared by NobleBlocks on Nov 1, 2004 • 12:00 AM UTC

Authors:

Perchellet EM

Wang Y

Weber RL

Abstract

Synthetic triptycene analogs (TT code number) mimic the antitumor effects of daunorubicin (DAU) in vitro, but have the advantage of blocking nucleoside transport, inhibiting both DNA topoisomerase I and II activities, and retaining their efficacy in multidrug-resistant (MDR) tumor cells. Since TT bi...

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