The stem cell organisation, and the proliferative and gene expression profile of Barrett's epithelium, replicates pyloric-type gastric glands

L. Lavery, Danielle; M. Nicholson, Anna; Poulsom, Richard; Jeffery, Rosemary; Hussain, Alia; J. Gay, Laura; Jankowski, Janusz; Zeki, Sebastian; Barr, Hugh; Harrison, Rebecca; J. Going, James; Kadirkamanathan, Sritharan; E. Davis, Peter; Underwood, Tim; Novelli, Marco; Rodriguez‐Justo, Manuel; A. Shepherd, Neil; Jansen, Marnix; A. Wright, Nicholas; A.C. McDonald, Stuart

doi:10.1136/gutjnl-2013-306508

Public

The stem cell organisation, and the proliferative and gene expression profile of Barrett's epithelium, replicates pyloric-type gastric glands

Published in Gut • Feb 18, 2014

Authors:

Danielle L. Lavery

Anna M. Nicholson

Richard Poulsom

Abstract

OBJECTIVE: Barrett's oesophagus shows appearances described as 'intestinal metaplasia', in structures called 'crypts' but do not typically display crypt architecture. Here, we investigate their relationship to gastric glands. METHODS: Cell proliferation and migration within Barrett's glands was asse...

Subject

Biology

LGR5

Gastric glands

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