Cholesterol Efflux Capacity, High-Density Lipoprotein Function, and Atherosclerosis

Khera, Amit; Cuchel, Marina; de la Llera-Moya, Margarita; Rodrigues, Amrith; F. Burke, Megan; Jafri, Kashif; French, Benjamin; A. Phillips, Julie; Mucksavage, Megan; L. Wilensky, Robert; R. Mohler, Emile; H. Rothblat, George; J. Rader, Daniel

doi:10.1056/nejmoa1001689

Public

Cholesterol Efflux Capacity, High-Density Lipoprotein Function, and Atherosclerosis

Published in New England Journal of Medicine • Jan 12, 2011

Authors:

Amit Khera

Marina Cuchel

Margarita de la Llera-Moya

Abstract

BACKGROUND: High-density lipoprotein (HDL) may provide cardiovascular protection by promoting reverse cholesterol transport from macrophages. We hypothesized that the capacity of HDL to accept cholesterol from macrophages would serve as a predictor of atherosclerotic burden. METHODS: We measured cho...

Subject

Medicine

Odds ratio

Cholesterol

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