SREBP Activity Is Regulated by mTORC1 and Contributes to Akt-Dependent Cell Growth

Porstmann, Thomas; R. Santos, Cláudio; Griffiths, B; Cully, Megan; Wu, Mary; J. Leevers, Sally; R. Griffiths, John; Chung, Yuen‐Li; Schulze, Almut

doi:10.1016/j.cmet.2008.07.007

Public

SREBP Activity Is Regulated by mTORC1 and Contributes to Akt-Dependent Cell Growth

Published in Cell Metabolism • Sep 1, 2008

Authors:

Thomas Porstmann

Cláudio R. Santos

B Griffiths

Abstract

Cell growth (accumulation of mass) needs to be coordinated with metabolic processes that are required for the synthesis of macromolecules. The PI3-kinase/Akt signaling pathway induces cell growth via activation of complex 1 of the target of rapamycin (TORC1). Here we show that Akt-dependent lipogene...

Subject

mTORC1

Cell biology

Protein kinase B

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