Constitutive and regulated α-secretase cleavage of Alzheimer’s amyloid precursor protein by a disintegrin metalloprotease

Lammich, Sven; Kojro, Elżbieta; Postina, Rolf; L. Gilbert, Sandra; Pfeiffer, Roland; Jasionowski, Marek; Haass, Christian; Fahrenholz, Falk

doi:10.1073/pnas.96.7.3922

Public

Constitutive and regulated α-secretase cleavage of Alzheimer’s amyloid precursor protein by a disintegrin metalloprotease

Published in Proceedings of the National Academy of Sciences • Mar 30, 1999

Authors:

Sven Lammich

Elżbieta Kojro

Rolf Postina

Abstract

Amyloid beta peptide (Abeta), the principal proteinaceous component of amyloid plaques in brains of Alzheimer's disease patients, is derived by proteolytic cleavage of the amyloid precursor protein (APP). Proteolytic cleavage of APP by a putative alpha-secretase within the Abeta sequence precludes t...

Subject

Amyloid precursor protein

ADAM10

P3 peptide

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