A multicenter, prospective, randomized, double‐blind, placebo‐controlled trial of corticosteroids and intravenous cyclophosphamide followed by oral azathioprine for the treatment of pulmonary fibrosis in scleroderma

K. Hoyles, Rachel; Ellis, R; Wellsbury, Jessica; Lees, Belinda; Newlands, Pauline; Goh, Nicole; A. Roberts, Christopher; R. Desai, Sujal; L. Herrick, Ariane; McHugh, Neil; Foley, Noeleen; B. Pearson, Stanley; Emery, Paul; J. Veale, Douglas; P. Denton, Christopher; U. Wells, Athol; M. Black, Carol; M. du Bois, Roland

doi:10.1002/art.22204

Public

A multicenter, prospective, randomized, double‐blind, placebo‐controlled trial of corticosteroids and intravenous cyclophosphamide followed by oral azathioprine for the treatment of pulmonary fibrosis in scleroderma

Published in Arthritis & Rheumatism • Nov 28, 2006

Authors:

Rachel K. Hoyles

R Ellis

Jessica Wellsbury

Abstract

OBJECTIVE: The lack of randomized controlled trials (RCTs) in pulmonary fibrosis in systemic sclerosis (SSc) has hampered an evidence-based approach to treatment. This RCT was undertaken to investigate the effects of intravenous (IV) cyclophosphamide (CYC) followed by azathioprine (AZA) treatment in...

Subject

DLCO

Medicine

Placebo

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