A multicenter, prospective, randomized, double-blind, placebo-controlled trial of corticosteroids and intravenous cyclophosphamide followed by oral azathioprine for the treatment of pulmonary fibrosis in scleroderma.

RK, Hoyles; RW, Ellis; J, Wellsbury; B, Lees; P, Newlands; NS, Goh; C, Roberts; S, Desai; AL, Herrick; NJ, McHugh; NM, Foley; SB, Pearson; P, Emery; DJ, Veale; CP, Denton; AU, Wells; CM, Black; Bois RM, du

doi:10.1002/art.22204

Public

A multicenter, prospective, randomized, double-blind, placebo-controlled trial of corticosteroids and intravenous cyclophosphamide followed by oral azathioprine for the treatment of pulmonary fibrosis in scleroderma.

Shared by NobleBlocks on Dec 1, 2006 • 12:00 AM UTC

Authors:

Hoyles RK

Ellis RW

Wellsbury J

Abstract

Objective The lack of randomized controlled trials (RCTs) in pulmonary fibrosis in systemic sclerosis (SSc) has hampered an evidence-based approach to treatment. This RCT was undertaken to investigate the effects of intravenous (IV) cyclophosphamide (CYC) followed by azathioprine (AZA) treatment in ...

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