Safety and Immunogenicity of an HIV-1 Gag DNA Vaccine with or without IL-12 and/or IL-15 Plasmid Cytokine Adjuvant in Healthy, HIV-1 Uninfected Adults

A. Kalams, Spyros; Parker, Scott; Jin, Xia; Elizaga, Marnie; Metch, Barbara; Haitian Wang, Maggie; Hural, John; D. Lubeck, Michael; H. Eldridge, John; Cardinali, M.; A. Blattner, William; Sobieszczyk, Magda; Suriyanon, Vinai; Olhovetchi Kalichman, Artur; B. Weiner, David; R. Baden, Lindsey; NIAID HIV Vaccine Trials Network, the

doi:10.1371/journal.pone.0029231

Public

Safety and Immunogenicity of an HIV-1 Gag DNA Vaccine with or without IL-12 and/or IL-15 Plasmid Cytokine Adjuvant in Healthy, HIV-1 Uninfected Adults

Published in PLoS ONE • Jan 5, 2012

Authors:

Spyros A. Kalams

Scott Parker

Xia Jin

Abstract

BACKGROUND: DNA vaccines are a promising approach to vaccination since they circumvent the problem of vector-induced immunity. DNA plasmid cytokine adjuvants have been shown to augment immune responses in small animals and in macaques. METHODOLOGY/PRINCIPAL FINDINGS: We performed two first in human ...

Subject

DNA vaccination

Immunogenicity

Virology

Research Assistant

AI chat, annotations, notes & similar papers

Finding related papers...

Discussions

(0)

No comments yet

Be the first to share your thoughts!