ABCA1 and ABCG1 Synergize to Mediate Cholesterol Export to ApoA-I

C. Gelissen, Ingrid; Harris, Matthew; Rye, Kerry‐Anne; M. Quinn, Carmel; J. Brown, Andrew; Kockx, Maaike; P. Cartland, Siân; Packianathan, M.; Kritharides, Leonard; Jessup, Wendy

doi:10.1161/01.atv.0000200082.58536.e1

Public

ABCA1 and ABCG1 Synergize to Mediate Cholesterol Export to ApoA-I

Published in Arteriosclerosis Thrombosis and Vascular Biology • Dec 16, 2005

Authors:

Ingrid C. Gelissen

Matthew Harris

Kerry‐Anne Rye

Abstract

OBJECTIVE: To study the acceptor specificity for human ABCG1 (hABCG1)-mediated cholesterol efflux. METHODS AND RESULTS: Cells overexpressing hABCG1 were created in Chinese Hamster Ovary (CHO-K1) cells and characterized in terms of lipid composition. hABCG1 expressed in these cells formed homodimers ...

Subject

ABCG1

ABCA1

Cholesterol

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