Mode of action and human relevance analysis for nuclear receptor-mediated liver toxicity: A case study with phenobarbital as a model constitutive androstane receptor (CAR) activator

R. Elcombe, Clifford; C. Peffer, Richard; C. Wolf, Douglas; P. Bailey, Jason; Bars, R.; Bell, David; C. Cattley, Russell; Ferguson, Stephen; R. Geter, David; K. Goetz, Amber; I. Goodman, Jay; Hester, Susan; Jacobs, Abigail; J. Omiecinski, Curtis; Schoeny, Rita; Xie, Wen; G. Lake, Brian

doi:10.3109/10408444.2013.835786

Public

Mode of action and human relevance analysis for nuclear receptor-mediated liver toxicity: A case study with phenobarbital as a model constitutive androstane receptor (CAR) activator

Published in Critical Reviews in Toxicology • Nov 4, 2013

Authors:

Clifford R. Elcombe

Richard C. Peffer

Douglas C. Wolf

Abstract

The constitutive androstane receptor (CAR) and pregnane X receptor (PXR) are important nuclear receptors involved in the regulation of cellular responses from exposure to many xenobiotics and various physiological processes. Phenobarbital (PB) is a non-genotoxic indirect CAR activator, which induces...

Subject

Constitutive androstane receptor

Pregnane X receptor

Nuclear receptor

Research Assistant

AI chat, annotations, notes & similar papers

Finding related papers...

Discussions

(0)

No comments yet

Be the first to share your thoughts!