Substitution of nevirapine, efavirenz, or abacavir for protease inhibitors in patients with human immunodeficiency virus infection.

E, Martínez; JA, Arnaiz; D, Podzamczer; D, Dalmau; E, Ribera; P, Domingo; H, Knobel; M, Riera; E, Pedrol; L, Force; JM, Llibre; F, Segura; C, Richart; C, Cortés; M, Javaloyas; M, Aranda; A, Cruceta; Lazzari E, de; JM, Gatell

doi:10.1056/nejmoa021589

Public

Substitution of nevirapine, efavirenz, or abacavir for protease inhibitors in patients with human immunodeficiency virus infection.

Shared by NobleBlocks on Sep 1, 2003 • 12:00 AM UTC

Authors:

Martínez E

Arnaiz JA

Podzamczer D

Abstract

Background We assessed the strategy of substituting nevirapine, efavirenz, or abacavir for a protease inhibitor in patients infected with human immunodeficiency virus type 1 (HIV-1) in whom virologic suppression had been achieved.Methods We randomly assigned 460 adults who were taking two nucleoside...

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