Substitution of Nevirapine, Efavirenz, or Abacavir for Protease Inhibitors in Patients with Human Immunodeficiency Virus Infection

Martínez, Estebán; A. Arnaiz, Juan; Podzamczer, Daniel; Dalmau, David; Ribera, Esteban; Domingo, Peré; Knobel, Hernando; Riera, Melcior; Pedrol, Enric; Force, Lluís; M. Llibre, Josep; Segura, Ferrán; Richart, Cristóbal; Cortés, Cristina; Javaloyas, M; Aranda, Miquel; Cruceta, Ana; de Lazzari, Elisa; M. Gatell, José

doi:10.1056/nejmoa021589

Public

Substitution of Nevirapine, Efavirenz, or Abacavir for Protease Inhibitors in Patients with Human Immunodeficiency Virus Infection

Published in New England Journal of Medicine • Sep 10, 2003

Authors:

Estebán Martínez

Juan A. Arnaiz

Daniel Podzamczer

Abstract

BACKGROUND: We assessed the strategy of substituting nevirapine, efavirenz, or abacavir for a protease inhibitor in patients infected with human immunodeficiency virus type 1 (HIV-1) in whom virologic suppression had been achieved. METHODS: We randomly assigned 460 adults who were taking two nucleos...

Subject

Nevirapine

Efavirenz

Abacavir

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