Quinoxalinediones: potent competitive non-NMDA glutamate receptor antagonists.

T, Honoré; SN, Davies; J, Drejer; EJ, Fletcher; P, Jacobsen; D, Lodge; FE, Nielsen

doi:10.1126/science.2899909

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Quinoxalinediones: potent competitive non-NMDA glutamate receptor antagonists.

Shared by NobleBlocks on Aug 1, 1988 • 12:00 AM UTC

Authors:

Honoré T

Davies SN

Drejer J

Abstract

The N-methyl-D-aspartate (NMDA)-subtype of glutamate receptors has been well described as a result of the early appearance of NMDA antagonists, but no potent antagonist for the "non-NMDA" glutamate receptors has been available. Quinoxalinediones have now been found to be potent and competitive antag...

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