Biodistribution of rAAV Vectors Following Intraocular Administration: Evidence for the Presence and Persistence of Vector DNA in the Optic Nerve and in the Brain

Provost, Nathalie; Le Meur, Guylène; Weber, Michel; Mendes-Madeira, Alexandra; Podevin, Guillaume; Chérel, Yan; Colle, Marie-Anne; Deschamps, Jack‐Yves; Moullier, Philippe; Rolling, Fabienne

doi:10.1016/j.ymthe.2004.09.022

Public

Biodistribution of rAAV Vectors Following Intraocular Administration: Evidence for the Presence and Persistence of Vector DNA in the Optic Nerve and in the Brain

Published in Molecular Therapy • Dec 16, 2004

Authors:

Nathalie Provost

Guylène Le Meur

Michel Weber

Abstract

The purpose of our study was to evaluate the biodistribution of rAAV vectors following subretinal or intravitreal injection. In rats, we performed subretinal or intravitreal injections of rAAV-2/2.CMV.gfp. In large animals, rAAV-2/4.CMV.gfp or rAAV-2/5.CMV.gfp was delivered into the subretinal space...

Subject

Vector (molecular biology)

Optic nerve

Viral vector

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