<i>MED12</i> , the <i>Mediator Complex Subunit 12</i> Gene, Is Mutated at High Frequency in Uterine Leiomyomas

Mäkinen, Netta; Mehine, Miika; Tolvanen, Jaana; Kaasinen, Eevi; Li, Yilong; Lehtonen, Heli; Gentile, Massimiliano; Yan, Jian; Enge, Martin; Taipale, Minna; Aavikko, Mervi; Katainen, Riku; Virolainen, Elina; Böhling, Tom; A. Koski, Taru; Launonen, Virpi; Sjöberg, Jari; Taipale, Jussi; Vahteristo, Pia; A. Aaltonen, Lauri

doi:10.1126/science.1208930

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MED12 , the Mediator Complex Subunit 12 Gene, Is Mutated at High Frequency in Uterine Leiomyomas

Published in Science • Aug 25, 2011

Authors:

Netta Mäkinen

Miika Mehine

Jaana Tolvanen

Abstract

Uterine leiomyomas, or fibroids, are benign tumors that affect millions of women worldwide and that can cause considerable morbidity. To study the genetic basis of this tumor type, we examined 18 uterine leiomyomas derived from 17 different patients by exome sequencing and identified tumor-specific ...

Subject

Biology

Mediator

Carcinogenesis

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